MOTS-C 10mg

MOTS-C 10mg — Mitochondrial-Derived Peptide

Until 2015, mitochondrial DNA was thought to encode exactly 13 proteins, 22 tRNAs, and 2 rRNAs. Then Lee et al. found MOTS-C 10mg — a 16-amino-acid peptide hiding in a short open reading frame within the 12S rRNA gene. Its discovery revealed an entirely new category of bioactive molecules: peptides encoded by the mitochondrial genome that signal to the nucleus, telling it about the cell’s metabolic state. Mitochondria are not just the powerhouse. They are also the messenger.

Specifications

An indirect route to AMPK

MOTS-C does not hit AMPK directly the way pharmaceutical activators do. Instead, it inhibits the folate cycle, which causes AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) to accumulate. AICAR is an endogenous AMPK activator. So MOTS-C activates the central energy sensor of the cell, but through an upstream metabolic bottleneck rather than direct kinase binding. Under stress conditions, the peptide translocates from mitochondria to the nucleus to regulate gene expression — a retrograde signal where the organelle talks back to the genome.

MOTS-C vs NAD+

Both sit at the intersection of energy metabolism and cellular signaling, but through different nodes. NAD+ fuels sirtuins, PARPs, and the electron transport chain. MOTS-C activates AMPK through the folate cycle. Complementary pathways, not redundant ones. Peptide Bio Sciences LTD carries both. Buy MOTS-C 10mg

Research applications

• AMPK pathway activation and downstream signaling
• Folate-methionine cycle and AICAR accumulation
• Mitochondrial-nuclear retrograde signaling
• Glucose uptake and fatty acid oxidation studies
• Cellular stress response and metabolic adaptation

MOTS-C 10mg is Frequently paired with

• BPC-157 5mg — Complementary recovery pathways.
• NAD+ 1000mg — AMPK + sirtuin axis research.

Quality and testing

Third-party tested with mass spectrometry confirmation. Batch-specific COAs available.

Storage

• Lyophilized: -20°C
• Reconstituted: 2-8°C, use within 30 days

For laboratory research use only. Not for human or veterinary use.